Chronic liver disease: noninvasive subharmonic aided pressure estimation of hepatic venous pressure gradient.

ABSTRACT:

Purpose

To compare subharmonic aided pressure estimation (SHAPE) with pressure catheter-based measurements in human patients with chronic liver disease undergoing transjugular liver biopsy.

Materials and methods

This HIPAA-compliant study had U.S. Food and Drug Administration and institutional review board approval, and written informed consent was obtained from all participants. Forty-five patients completed this study between December 2010 and December 2011. A clinical ultrasonography (US) scanner was modified to obtain SHAPE data. After transjugular liver biopsy with pressure measurements as part of the standard of care, 45 patients received an infusion of a microbubble US contrast agent and saline. During infusion, SHAPE data were collected from a portal and hepatic vein

SUBMITTER: Eisenbrey JR 

PROVIDER: S-EPMC3721058 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature