Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases.

ABSTRACT:

Background

While genome-wide association studies (GWAS) of complex traits have revealed thousands of reproducible genetic associations to date, these loci collectively confer very little of the heritability of their respective diseases and, in general, have contributed little to our understanding the underlying disease biology. Physical protein interactions have been utilized to increase our understanding of human Mendelian disease loci but have yet to be fully exploited for complex traits.

Methods

We hypothesized that protein interaction modeling of GWAS findings could highlight important disease-associated loci and unveil the role of their network topology in the genetic architecture of diseases with complex inheritance.

Results

Network modeling of proteins associat

SUBMITTER: Lee Y 

PROVIDER: S-EPMC3721168 | biostudies-literature | 2013 Jul-Aug

REPOSITORIES: biostudies-literature