Horse versus rabbit antithymocyte globulin in acquired aplastic anemia.

ABSTRACT:

Background

In severe acquired aplastic anemia, hematopoietic failure is the result of immune-mediated destruction of bone marrow stem and progenitor cells. Immunosuppressive therapy with antithymocyte globulin (ATG) plus cyclosporine is an effective alternative to stem-cell transplantation and improves blood counts and survival. Although horse ATG is the standard therapy, rabbit ATG is more potent in depleting peripheral-blood lymphocytes and is preferred in other clinical circumstances.

Methods

From December 2005 through July 2010, we performed a randomized trial comparing these two ATG formulations in conventional regimens. Patients were treated at a single facility. The primary outcome was hematologic response at 6 months, as determined by blood counts. The study was desi

SUBMITTER: Scheinberg P 

PROVIDER: S-EPMC3721503 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature