Effect of paroxetine on physiological response to stress and smoking.

ABSTRACT:

Objective

Smokers often smoke during stressful events, which leads to large increases in cardiovascular measures such as blood pressure (BP) and heart rate (HR). Because exaggerated cardiovascular response to stress is associated with cardiovascular disease risk, this study examined paroxetine's effect on the physiological response to combining stress and smoking.

Methods

Sixty-two participants completed this randomized, double-blind, crossover study in which BP, HR, plasma epinephrine, norepinephrine, and cortisol concentrations were measured at rest, while smoking, and during a speech and math task. Laboratory sessions occurred after 1 month of paroxetine and after 1 month of placebo.

Results

Significant increases occurred for all measures (except cortisol) during s

SUBMITTER: Kotlyar M 

PROVIDER: S-EPMC3721515 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature