Influence of crossover on mortality in a randomized study of revascularization in patients with systolic heart failure and coronary artery disease.

ABSTRACT:

Background

To assess the influence of therapy crossovers on treatment comparisons and mortality at 5 years in patients with ischemic heart disease and heart failure randomly assigned to medical therapy alone (MED) or to MED and coronary artery bypass graft (CABG) surgery in the Surgical Treatment for Ischemic Heart Failure (STICH) trial.

Methods and results

The influence of early crossover (within the first year after randomization) on 5-year mortality was assessed using time-dependent multivariable Cox models. CABG was performed in 65/602 patients (10.8%) assigned to MED, and 55/610 patients (9.0%) assigned to CABG received MED only. Common reasons for crossover from MED to CABG were progressive symptoms or acute decompensation. MED-assigned patients who underwent CABG had

SUBMITTER: Doenst T 

PROVIDER: S-EPMC3721746 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature