Genetic heterogeneity in colorectal cancer associations between African and European americans.

ABSTRACT:

Background & aims

Genome-wide association studies of colorectal cancer (CRC) have identified risk variants in 10 genomic regions. None of these studies included African Americans, who have the highest incidence and mortality from CRC in the United States. For the 10 genomic regions, we performed an association study of Americans of African and European descent.

Methods

We genotyped 22 single nucleotide polymorphisms (SNPs) in DNA samples from 1194 patients with CRC (795 African Americans and 399 European Americans) and 1352 controls (985 African Americans and 367 European Americans). At chromosome 8q24.21 region 3, we analyzed 6 SNPs from 1000 African American cases and 1393 controls. Association testing was done using multivariate logistic regression controlling for ancestr

SUBMITTER: Kupfer SS 

PROVIDER: S-EPMC3721963 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature