Altered activation in fronto-striatal circuits during sequential processing of conflict in unmedicated adults with obsessive-compulsive disorder.

ABSTRACT:

Background

The aim of this study was to examine the functioning of fronto-striatal brain circuits that support self-regulatory capacities including conflict resolution and sequential processing in unmedicated adults with obsessive-compulsive disorder (OCD).

Methods

We compared functional magnetic resonance imaging blood oxygen level-dependent response in 22 adults with OCD with 22 healthy, age-matched control subjects during performance of a Simon Spatial Incompatibility task. We used general linear modeling to compare groups in their patterns of brain activation during correct responses to conflict-laden stimuli and explore the effects of trial sequence on group differences.

Results

Behavioral performance on the Simon task did not differ between groups. In response t

SUBMITTER: Marsh R 

PROVIDER: S-EPMC3722261 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature