Developmental disruption of gamma-aminobutyric acid function in the medial prefrontal cortex by noncontingent cocaine exposure during early adolescence.

ABSTRACT:

Background

Drug experimentation during adolescence is associated with increased risk of drug addiction relative to any other age group. To further understand the neurobiology underlying such liability, we investigate how early adolescent cocaine experience impacts medial prefrontal cortex (mPFC) network function in adulthood.

Methods

A noncontingent administration paradigm was used to assess the impact of early adolescent cocaine treatment (rats; postnatal days [PD] 35-40) on the overall inhibitory regulation of mPFC activity in adulthood (PD 65-75) by means of histochemical and in vivo electrophysiological measures combined with pharmacologic manipulations.

Results

Cocaine exposure during early adolescence yields a distinctive hypermetabolic prefrontal cortex state t

SUBMITTER: Cass DK 

PROVIDER: S-EPMC3722277 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature