Evaluating reported candidate gene associations with polycystic ovary syndrome.

ABSTRACT:

Objective

To replicate variants in candidate genes associated with polycystic ovary syndrome (PCOS) in a population of European women with PCOS and control subjects.

Design

Case-control association analysis and meta-analysis.

Setting

Major academic hospital.

Patient(s)

Women of European ancestry with PCOS (n = 525) and controls (n = 472), aged 18-45 years.

Intervention(s)

Variants previously associated with PCOS in candidate gene studies were genotyped (n = 39). Metabolic, reproductive, and anthropomorphic parameters were examined as a function of the candidate variants. All genetic association analyses were adjusted for age, body mass index, and ancestry and were reported after correction for multiple testing.

Main outcome measure(s)

Association

SUBMITTER: Pau C 

PROVIDER: S-EPMC3722586 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature