Investigation of cytocrom c oxidase gene subunits expression on the Multiple sclerosis.

ABSTRACT:

Introduction

Multiple sclerosis (MS) is an autoimmune inflamatory disease, which affects the (Central Nervous System) and leads to the destruction of myelin and atrophy of the axons. Genetic factors, in addition to environmental ones, seem to play a role in MS. Numerous studies have reported mitochondrial defects including a reduction in cytochrome c oxidase (COX) complex function related to the reduction of mitochondrial genes expression in the cortex tissue of patients with MS have been reported.

Materials and methods

This study aimed to assess COX5B and COX2 genes expression in MS patients and compare it with normal subjects. We determine expression levels of genes COX5B and COX2, and also gene reference ß-actine using real-time polymerase chain reaction (RT-PCR) method.

SUBMITTER: Safavizadeh N 

PROVIDER: S-EPMC3722625 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature