GRK-6 mediates FSH action synergistically enhanced by estrogen and the oocyte in rat granulosa cells.

ABSTRACT: Estrogen is known to play a pivotal role in granulosa cell responses to follicle-stimulating hormone (FSH) that is critical for the establishment of dominant follicles and subsequent ovulation in mammals. Thus, elucidating the cellular and molecular mechanisms that regulate FSH activity is important to understand female fertility. We previously discovered that the oocyte is required for estrogen to exert its positive effects on FSH activity in rat granulosa cells. This finding supports the new concept that estrogen action in granulosa cells is mediated by the oocyte. In the current study, we explored the underlying mechanism. In the presence of oocytes, estrogens enhanced FSH-induced increases in aromatase, steroidogenic acute regulatory protein and FSH receptor mRNA expression as well as

SUBMITTER: Miyoshi T 

PROVIDER: S-EPMC3722898 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature