Ontology highlight
ABSTRACT:
SUBMITTER: Bockhorn J
PROVIDER: S-EPMC3723106 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
Chemotherapy resistance frequently drives tumour progression. However, the underlying molecular mechanisms are poorly characterized. Epithelial-to-mesenchymal transition has been shown to correlate with therapy resistance, but the functional link and signalling pathways remain to be elucidated. Here we report that microRNA-30c, a human breast tumour prognostic marker, has a pivotal role in chemoresistance by a direct targeting of the actin-binding protein twinfilin 1, which promotes epithelial-t ...[more]