Photoredox activation for the direct β-arylation of ketones and aldehydes.

ABSTRACT: The direct β-activation of saturated aldehydes and ketones has long been an elusive transformation. We found that photoredox catalysis in combination with organocatalysis can lead to the transient generation of 5π-electron β-enaminyl radicals from ketones and aldehydes that rapidly couple with cyano-substituted aryl rings at the carbonyl β-position. This mode of activation is suitable for a broad range of carbonyl β-functionalization reactions and is amenable to enantioselective catalysis.

SUBMITTER: Pirnot MT 

PROVIDER: S-EPMC3723331 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature