Changing profile of rotavirus genotypes in Bangladesh, 2006-2012.

ABSTRACT:

Background

Rotavirus is the leading cause of severe diarrhea in infants and young children worldwide including Bangladesh. Unlike what was seen in high-income countries, the licensed rotavirus vaccines did not show high efficacy in Bangladeshi trials. We assessed rotavirus prevalence and genotypes in Bangladesh over six-year period to provide baseline information on the rotavirus burden and changing profile in the country.

Methods

This study was conducted from June 2006 to May 2012 in Matlab, Bangladesh. Group A rotaviruses were detected in stools collected from diarrhea patients by ELISA and genotyped using multiplex reverse transcription PCR followed by nucleotide sequencing.

Results

Of the 9678 stool samples, 20.3% were positive for rotavirus. The most predominant

SUBMITTER: Afrad MH 

PROVIDER: S-EPMC3723515 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature