Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson's patients leukocytes.

ABSTRACT:

Background

Nonsense-Mediated decay (NMD) selectively degrades mRNA transcripts that carry premature stop codons. NMD is often triggered by alternative splicing (AS) modifications introducing such codons. NMD plays an important regulatory role in brain neurons, but the in vivo dynamics of AS and NMD changes in neurological diseases and under treatment were scarcely explored.

Results

Here, we report exon arrays analysis of leukocyte mRNA AS events prior to and following Deep Brain Stimulation (DBS) neurosurgery, which efficiently improves the motor symptoms of Parkinson's disease (PD), the leading movement disorder, and is increasingly applied to treat other diseases. We also analyzed publicly available exon array dataset of whole blood cells from mixed early and advanced PD p

SUBMITTER: Soreq L 

PROVIDER: S-EPMC3723527 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature