Spatially explicit modeling of schistosomiasis risk in eastern China based on a synthesis of epidemiological, environmental and intermediate host genetic data.

ABSTRACT: Schistosomiasis japonica is a major parasitic disease threatening millions of people in China. Though overall prevalence was greatly reduced during the second half of the past century, continued persistence in some areas and cases of re-emergence in others remain major concerns. As many regions in China are approaching disease elimination, obtaining quantitative data on Schistosoma japonicum parasites is increasingly difficult. This study examines the distribution of schistosomiasis in eastern China, taking advantage of the fact that the single intermediate host serves as a major transmission bottleneck. Epidemiological, population-genetic and high-resolution ecological data are combined to construct a predictive model capable of estimating the probability that schistosomiasis occurs in a

SUBMITTER: Schrader M 

PROVIDER: S-EPMC3723594 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature