Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.

ABSTRACT:

Purpose

Genetic variation may influence chemotherapy response and overall survival in cancer patients.

Experimental design

We conducted a genome-wide scan in 535 advanced-stage non-small cell lung cancer (NSCLC) patients from two independent cohorts (307 from Nanjing and 228 from Beijing). A replication was carried out on an independent cohort of 340 patients from Southeastern China followed by a second validation on 409 patients from the Massachusetts General Hospital (Boston, MA).

Results

Consistent associations with NSCLC survival were identified for five single-nucleotide polymorphisms (SNP) in Chinese populations with P values ranging from 3.63 × 10(-5) to 4.19 × 10(-7) in the additive genetic model. The minor allele of three SNPs (rs7629386 at 3p22.1, rs969088 a

SUBMITTER: Hu L 

PROVIDER: S-EPMC3723686 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature