Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: a randomized, sham-controlled study.

ABSTRACT:

Background

The pain and autonomic symptoms of cluster headache (CH) result from activation of the trigeminal parasympathetic reflex, mediated through the sphenopalatine ganglion (SPG). We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).

Methods

A multicenter, multiple CH attack study of an implantable on-demand SPG neurostimulator was conducted in patients suffering from refractory CCH. Each CH attack was randomly treated with full, sub-perception, or sham stimulation. Pain relief at 15 minutes following SPG stimulation and device- or procedure-related serious adverse events (SAEs) were evaluated.

Findings

Thirty-two patients were enrolled and 28 completed the randomized experimental period. Pain relief was achieved in 67.1% of f

SUBMITTER: Schoenen J 

PROVIDER: S-EPMC3724276 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature