Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib.

ABSTRACT:

Background

Approximately 50% of melanomas harbor activating (V600) mutations in the serine-threonine protein kinase B-RAF (BRAF). The oral BRAF inhibitor vemurafenib (PLX4032) frequently produced tumor regressions in patients with BRAF V600-mutant metastatic melanoma in a phase 1 trial and improved overall survival in a phase 3 trial.

Methods

We designed a multicenter phase 2 trial of vemurafenib in patients with previously treated BRAF V600-mutant metastatic melanoma to investigate the efficacy of vemurafenib with respect to overall response rate (percentage of treated patients with a tumor response), duration of response, and overall survival. The primary end point was the overall response rate as ascertained by the independent review committee; overall survival was a seco

SUBMITTER: Sosman JA 

PROVIDER: S-EPMC3724515 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature