A chemical platform for improved induction of human iPSCs.

ABSTRACT: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.

SUBMITTER: Lin T 

PROVIDER: S-EPMC3724527 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature