Classification of protein motifs based on subcellular localization uncovers evolutionary relationships at both sequence and functional levels.

ABSTRACT:

Background

Most proteins have evolved in specific cellular compartments that limit their functions and potential interactions. On the other hand, motifs define amino acid arrangements conserved between protein family members and represent powerful tools for assigning function to protein sequences. The ideal motif would identify all members of a protein family but in practice many motifs identify both family members and unrelated proteins, referred to as True Positive (TP) and False Positive (FP) sequences, respectively.

Results

To address the relationship between protein motifs, protein function and cellular localization, we systematically assigned subcellular localization data to motif sequences from the comprehensive PROSITE sequence motif database. Using this data we anal

SUBMITTER: Parras-Molto M 

PROVIDER: S-EPMC3724711 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature