IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort.

ABSTRACT:

Objective

Within the interleukin-1 (IL-1) cytokine family, IL-1 receptor antagonist (IL1RN) gene variants have been associated with radiological severity of knee osteoarthritis (OA) in cross-sectional studies. The present study tested the relation between IL1RN gene variants and progression of knee OA assessed radiographically by change in Kellgren-Lawrence (KL) score over time.

Design

1153 Caucasian adults (age range: 44-89) from the Johnson County Osteoarthritis Project were evaluated for unequivocal radiographic evidence of knee OA at baseline, defined as KL score ≥2, and were re-examined after 4-11 years for radiographic changes typical of OA progression. IL1RN gene variants were tested for association with OA progression and for potential interaction with body mass inde

SUBMITTER: Wu X 

PROVIDER: S-EPMC3725144 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature