Ontology highlight
ABSTRACT:
SUBMITTER: Al Alam D
PROVIDER: S-EPMC3725282 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Developmental biology 20120720 2
Fibroblast growth factor (FGF) signaling to the epithelium and mesenchyme mediated by FGF10 and FGF9, respectively, controls cecal formation during embryonic development. In particular, mesenchymal FGF10 signals to the epithelium via FGFR2b to induce epithelial cecal progenitor cell proliferation. Yet the precise upstream mechanisms controlling mesenchymal FGF10 signaling are unknown. Complete deletion of Fgf9 as well as of Pitx2, a gene encoding a homeobox transcription factor, both lead to cec ...[more]