Side chain and backbone structure-dependent subcellular localization and toxicity of conjugated polymer nanoparticles.

ABSTRACT: The subcellular localization and toxicity of conjugated polymer nanoparticles (CPNs) are dependent on the chemical structure of the side chains and backbone. Primary amine-containing CPNs exhibit high Golgi localization with no toxicity. Incorporation of short ethylene oxide and tertiary amine side chains contributes to decreased Golgi localization and increased toxicity, respectively.

SUBMITTER: Mendez E 

PROVIDER: S-EPMC3725290 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature