Ontology highlight
ABSTRACT:
SUBMITTER: Croucher NJ
PROVIDER: S-EPMC3725542 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Croucher Nicholas J NJ Finkelstein Jonathan A JA Pelton Stephen I SI Mitchell Patrick K PK Lee Grace M GM Parkhill Julian J Bentley Stephen D SD Hanage William P WP Lipsitch Marc M
Nature genetics 20130505 6
Whole-genome sequencing of 616 asymptomatically carried Streptococcus pneumoniae isolates was used to study the impact of the 7-valent pneumococcal conjugate vaccine. Comparison of closely related isolates showed the role of transformation in facilitating capsule switching to non-vaccine serotypes and the emergence of drug resistance. However, such recombination was found to occur at significantly different rates across the species, and the evolution of the population was primarily driven by cha ...[more]