Interleukin 6 plasma concentration associates with cognitive decline: the northern Manhattan study.

ABSTRACT:

Background

Interleukin 6 (IL-6) is an inflammatory cytokine that has been associated with vascular disease and cognitive impairment, but few studies have examined these relationships in population-based studies that include Hispanic and Black people who often have a greater prevalence of vascular risk factors and are at an elevated risk of dementia than Whites. We examined relative elevations of plasma IL-6 concentrations in relation to cognitive decline in a stroke-free racially/ethnically diverse community-based sample from Northern Manhattan.

Methods

We used mixed effects models to measure the effect of IL-6 on change in performance on the modified Telephone Interview for Cognitive Status (TICS-m) measured annually in our cohort, adjusting for sociodemographic and vascula

SUBMITTER: Economos A 

PROVIDER: S-EPMC3725587 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature