Neuronal differentiation of embryonic stem cell derived neuronal progenitors can be regulated by stretchable conducting polymers.

ABSTRACT: Electrically conducting polymers are prospective candidates as active substrates for the development of neuroprosthetic devices. The utility of these substrates for promoting differentiation of embryonic stem cells paves viable routes for regenerative medicine. Here, we have tuned the electrical and mechanical cues provided to the embryonic stem cells during differentiation by precisely straining the conducting polymer (CP) coated, elastomeric-substrate. Upon straining the substrates, the neural differentiation pattern occurs in form of aggregates, accompanied by a gradient where substrate interface reveals a higher degree of differentiation. The CP domains align under linear stress along with the formation of local defect patterns leading to disruption of actin cytoskeleton of cells, and

SUBMITTER: Srivastava N 

PROVIDER: S-EPMC3725875 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature