Ontology highlight
ABSTRACT:
SUBMITTER: Arora P
PROVIDER: S-EPMC3726159 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Arora Pankaj P Wu Connie C Khan Abigail May AM Bloch Donald B DB Davis-Dusenbery Brandi N BN Ghorbani Anahita A Spagnolli Ester E Martinez Andrew A Ryan Allicia A Tainsh Laurel T LT Kim Samuel S Rong Jian J Huan Tianxiao T Freedman Jane E JE Levy Daniel D Miller Karen K KK Hata Akiko A Del Monte Federica F Vandenwijngaert Sara S Swinnen Melissa M Janssens Stefan S Holmes Tara M TM Buys Emmanuel S ES Bloch Kenneth D KD Newton-Cheh Christopher C Wang Thomas J TJ
The Journal of clinical investigation 20130715 8
Numerous common genetic variants have been linked to blood pressure, but no underlying mechanism has been elucidated. Population studies have revealed that the variant rs5068 (A/G) in the 3' untranslated region of NPPA, the gene encoding atrial natriuretic peptide (ANP), is associated with blood pressure. We selected individuals on the basis of rs5068 genotype (AG vs. AA) and fed them a low- or high-salt diet for 1 week, after which they were challenged with an intravenous saline infusion. On bo ...[more]