Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis.

ABSTRACT: The majority of patients with cancer undergo at least one surgical procedure as part of their treatment. Severe postsurgical infection is associated with adverse oncologic outcomes; however, the mechanisms underlying this phenomenon are unclear. Emerging evidence suggests that neutrophils, which function as the first line of defense during infections, facilitate cancer progression. Neutrophil extracellular traps (NETs) are extracellular neutrophil-derived DNA webs released in response to inflammatory cues that trap and kill invading pathogens. The role of NETs in cancer progression is entirely unknown. We report that circulating tumor cells become trapped within NETs in vitro under static and dynamic conditions. In a murine model of infection using cecal ligation and puncture, we demonstra

SUBMITTER: Cools-Lartigue J 

PROVIDER: S-EPMC3726160 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature