Markers of inflammation and coagulation may be modulated by enteral feeding strategy.

ABSTRACT:

Background

Although enteral nutrition (EN) is provided to most mechanically ventilated patients, the effect of specific feeding strategies on circulating markers of coagulation and inflammation is unknown.

Methods

Markers of inflammation (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, interferon [IFN]-γ, IL-6, IL-8, IL-10, IL-12) and coagulation (tissue factor [TF], plasminogen activator inhibitor-1) were measured at baseline (n = 185) and 6 days (n = 103) in mechanically ventilated intensive care unit patients enrolled in a randomized controlled study of trophic vs full-energy feeds to test the hypothesis that trophic enteral feeds would be associated with decreases in markers of inflammation and coagulation compared to full-energy feeds.

Results

There were no d

SUBMITTER: Bastarache JA 

PROVIDER: S-EPMC3726194 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature