Characterization of Cannabis sativa allergens.

ABSTRACT:

Background

Allergic sensitization to Cannabis sativa is rarely reported, but the increasing consumption of marijuana has resulted in an increase in the number of individuals who become sensitized. To date, little is known about the causal allergens associated with C sativa.

Objective

To characterize marijuana allergens in different components of the C sativa plant using serum IgE from marijuana sensitized patients.

Methods

Serum samples from 23 patients with a positive skin prick test result to a crude C sativa extract were evaluated. IgE reactivity was variable between patients and C sativa extracts. IgE reactivity to C sativa proteins in Western blots was heterogeneous and ranged from 10 to 70 kDa. Putative allergens derived from 2-dimensional gels were identified.<

SUBMITTER: Nayak AP 

PROVIDER: S-EPMC3726218 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature