Gene bionetworks that regulate ovarian primordial follicle assembly.

ABSTRACT:

Background

Primordial follicle assembly is the process by which ovarian primordial follicles are formed. During follicle assembly oocyte nests break down and a layer of pre-granulosa cells surrounds individual oocytes to form primordial follicles. The pool of primordial follicles formed is the source of oocytes for ovulation during a female's reproductive life.

Results

The current study utilized a systems approach to detect all genes that are differentially expressed in response to seven different growth factor and hormone treatments known to influence (increase or decrease) primordial follicle assembly in a neonatal rat ovary culture system. One novel factor, basic fibroblast growth factor (FGF2), was experimentally determined to inhibit follicle assembly. The different gro

SUBMITTER: Nilsson E 

PROVIDER: S-EPMC3726361 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature