Metallothionein 2A inhibits NF-?B pathway activation and predicts clinical outcome segregated with TNM stage in gastric cancer patients following radical resection.

ABSTRACT: Metallothionein 2A (MT2A) as a stress protein, plays a protective role in gastric mucosal barrier. Its role in the development of gastric cancer (GC) is unclear. The mechanism of MT2A will be investigated in gastric tumorigenesis.MT2A expression was detected in 973 gastric specimens. The biological function was determined through ectopic expressing MT2A in vitro and in vivo. The possible downstream effectors of MT2A were investigated in NF-?B signaling. The protein levels of MT2A, I?B-? and p-I?B-? (ser32/36) expression were analyzed in a subset of 258 patients by IHC staining. The prognostic effects of MT2A, status of I?B-? and TNM stage were evaluated using the Kaplan-Meier method and compared using the log-rank test.Decreased MT2A expression was detected in cell lines and primary tumors of GC. In clinical data, loss of MT2A (MT2A?+?in Normal (n =171, 76.0%); Intestinal metaplasia (n?=?118, 50.8%); GC (n?=?684. 22.4%, P?

SUBMITTER: Pan Y 

PROVIDER: S-EPMC3726370 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature