Evolutionary conservation of alternative splicing in chicken.

ABSTRACT: Alternative splicing represents a source of great diversity for regulating protein expression and function. It has been estimated that one-third to two-thirds of mammalian genes are alternatively spliced. With the sequencing of the chicken genome and analysis of transcripts expressed in chicken tissues, we are now in a position to address evolutionary conservation of alternative splicing events in chicken and mammals. Here, we compare chicken and mammalian transcript sequences of 41 alternatively-spliced genes and 50 frequently accessed genes. Our results support a high frequency of splicing events in chicken, similar to that observed in mammals.

SUBMITTER: Katyal S 

PROVIDER: S-EPMC3726401 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature