Neural network activation during a stop-signal task discriminates cocaine-dependent from non-drug-abusing men.

ABSTRACT: Cocaine dependence is defined by a loss of inhibitory control over drug-use behaviors, mirrored by measurable impairments in laboratory tasks of inhibitory control. The current study tested the hypothesis that deficits in multiple subprocesses of behavioral control are associated with reliable neural-processing alterations that define cocaine addiction. While undergoing functional magnetic resonance imaging (fMRI), 38 cocaine-dependent men and 27 healthy control men performed a stop-signal task of motor inhibition. An independent component analysis on fMRI time courses identified task-related neural networks attributed to motor, visual, cognitive and affective processes. The statistical associations of these components with five different stop-signal task conditions were selected for use i

SUBMITTER: Elton A 

PROVIDER: S-EPMC3726576 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature