Effect of trans fatty acid intake on LC-MS and NMR plasma profiles.

ABSTRACT:

Background

The consumption of high levels of industrial trans fatty acids (TFA) has been related to cardiovascular disease, diabetes and sudden cardiac death but the causal mechanisms are not well known. In this study, NMR and LC-MS untargeted metabolomics has been used as an approach to explore the impact of TFA intake on plasma metabolites.

Methodology/principal findings

In a double-blinded randomized controlled parallel-group study, 52 overweight postmenopausal women received either partially hydrogenated soybean oil, providing 15.7 g/day of TFA (trans18:1) or control oil with mainly oleic acid for 16 weeks. Subsequent to the intervention period, the subjects participated in a 12-week dietary weight loss program. Before and after the TFA intervention and after the weight

SUBMITTER: Gurdeniz G 

PROVIDER: S-EPMC3726671 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature