Whole blood gene expression analyses in patients with single versus recurrent venous thromboembolism.

ABSTRACT:

Introduction

Venous thromboembolism may recur in up to 30% of patients with a spontaneous venous thromboembolism after a standard course of anticoagulation. Identification of patients at risk for recurrent venous thromboembolism would facilitate decisions concerning the duration of anticoagulant therapy.

Objectives

In this exploratory study, we investigated whether whole blood gene expression data could distinguish subjects with single venous thromboembolism from subjects with recurrent venous thromboembolism.

Methods

40 adults with venous thromboembolism (23 with single event and 17 with recurrent events) on warfarin were recruited. Individuals with antiphospholipid syndrome or cancer were excluded. Plasma and serum samples were collected for biomarker testing, and P

SUBMITTER: Lewis DA 

PROVIDER: S-EPMC3726737 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature