Increments and duplication events of enzymes and transcription factors influence metabolic and regulatory diversity in prokaryotes.

ABSTRACT: In this work, the content of enzymes and DNA-binding transcription factors (TFs) in 794 non-redundant prokaryotic genomes was evaluated. The identification of enzymes was based on annotations deposited in the KEGG database as well as in databases of functional domains (COG and PFAM) and structural domains (Superfamily). For identifications of the TFs, hidden Markov profiles were constructed based on well-known transcriptional regulatory families. From these analyses, we obtained diverse and interesting results, such as the negative rate of incremental changes in the number of detected enzymes with respect to the genome size. On the contrary, for TFs the rate incremented as the complexity of genome increased. This inverse related performance shapes the diversity of metabolic and regulatory

SUBMITTER: Martinez-Nunez MA 

PROVIDER: S-EPMC3726781 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature