Daily ultrafiltration results in improved blood pressure control and more efficient removal of small molecules during hemodialysis.

ABSTRACT:

Background

Although prior studies have shown that frequent hemodialysis (HD) can lead to improved control of dry weight in end-stage renal disease patients, there are no clinical studies examining whether this can improve blood pressure (BP) control and can also shorten the dialysis time needed to achieve satisfactory removal of small molecules. Several models of wearable dialysis systems are now under various stages of development. These devices present the possibility of hemodialyzing patients to their dry weights. We have built a prototype of a wearable ultrafiltration (UF) device that can provide daily UF. Apart from better fluid control, we hypothesize that separating HD from UF will result in better BP control, and adequate weekly small molecule removal could be achieved with

SUBMITTER: Jones JP 

PROVIDER: S-EPMC3727139 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature