Ontology highlight
ABSTRACT:
SUBMITTER: Mesirca P
PROVIDER: S-EPMC3727310 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Mesirca Pietro P Marger Laurine L Toyoda Futoshi F Rizzetto Riccardo R Audoubert Matthieu M Dubel Stefan S Torrente Angelo G AG Difrancesco Mattia L ML Muller Jana Christina JC Leoni Anne-Laure AL Couette Brigitte B Nargeot Joël J Clapham David E DE Wickman Kevin K Mangoni Matteo E ME
The Journal of general physiology 20130715 2
Parasympathetic regulation of sinoatrial node (SAN) pacemaker activity modulates multiple ion channels to temper heart rate. The functional role of the G-protein-activated K(+) current (IKACh) in the control of SAN pacemaking and heart rate is not completely understood. We have investigated the functional consequences of loss of IKACh in cholinergic regulation of pacemaker activity of SAN cells and in heart rate control under physiological situations mimicking the fight or flight response. We us ...[more]