Genetic variation in CD83 and risks of cervical and vulvar cancers: a population-based case-control study.

ABSTRACT:

Objectives

The CD83 glycoprotein is a marker of dendritic cell maturation that may contribute to the T cell response to oncogenic human papillomavirus (HPV) infection. Whether single nucleotide polymorphisms (SNPs) in CD83 influence the risk of HPV-related genital cancers has not been adequately studied. We investigated whether the common genetic variation of the CD83 region was associated with the risks of cervical and vulvar cancers in a population-based case-control study conducted in the Seattle-Puget Sound Region.

Methods

A total of 17 tagSNPs were genotyped in the CD83 region of 886 cervical cases, 517 vulvar cases and 1100 controls. Odds ratio (OR) and 95% confidence intervals (CI) were computed to assess the risk of cervical and vulvar cancers. The interaction betwee

SUBMITTER: Bodelon C 

PROVIDER: S-EPMC3727898 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature