Identification of G protein-coupled receptor signaling pathway proteins in marine diatoms using comparative genomics.

ABSTRACT:

Background

The G protein-coupled receptor (GPCR) signaling pathway plays an essential role in signal transmission and response to external stimuli in mammalian cells. Protein components of this pathway have been characterized in plants and simpler eukaryotes such as yeast, but their presence and role in unicellular photosynthetic eukaryotes have not been determined. We use a comparative genomics approach using whole genome sequences and gene expression libraries of four diatoms (Pseudo-nitzschia multiseries, Thalassiosira pseudonana, Phaeodactylum tricornutum and Fragilariopsis cylindrus) to search for evidence of GPCR signaling pathway proteins that share sequence conservation to known GPCR pathway proteins.

Results

The majority of the core components of GPCR signaling were

SUBMITTER: Port JA 

PROVIDER: S-EPMC3727952 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature