Discovery of structural alterations in solid tumor oligodendroglioma by single molecule analysis.

ABSTRACT:

Background

Solid tumors present a panoply of genomic alterations, from single base changes to the gain or loss of entire chromosomes. Although aberrations at the two extremes of this spectrum are readily defined, comprehensive discernment of the complex and disperse mutational spectrum of cancer genomes remains a significant challenge for current genome analysis platforms. In this context, high throughput, single molecule platforms like Optical Mapping offer a unique perspective.

Results

Using measurements from large ensembles of individual DNA molecules, we have discovered genomic structural alterations in the solid tumor oligodendroglioma. Over a thousand structural variants were identified in each tumor sample, without any prior hypotheses, and often in genomic regions de

SUBMITTER: Ray M 

PROVIDER: S-EPMC3727977 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature