Vitamin D and subsequent all-age and premature mortality: a systematic review.

ABSTRACT:

Background

All-cause mortality in the population<65 years is 30% higher in Glasgow than in equally deprived Liverpool and Manchester. We investigated a hypothesis that low vitamin D in this population may be associated with premature mortality via a systematic review and meta-analysis.

Methods

Medline, EMBASE, Web of Science, the Cochrane Library and grey literature sources were searched until February 2012 for relevant studies. Summary statistics were combined in an age-stratified meta-analysis.

Results

Nine studies were included in the meta-analysis, representing 24,297 participants, 5,324 of whom died during follow-up. The pooled hazard ratio for low compared to high vitamin D demonstrated a significant inverse association (HR 1.19, 95% CI 1.12-1.27) between vitami

SUBMITTER: Rush L 

PROVIDER: S-EPMC3727990 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature