Cytomegalovirus (CMV) genotype in allogeneic hematopoietic stem cell transplantation.

ABSTRACT:

Background

Based on sequence variation in the UL55 gene that encodes glycoprotein B (gB), human cytomegalovirus (CMV) can be classified into four gB genotypes. Previous studies have suggested an association between CMV gB genotype and clinical outcome in patients who underwent an allogeneic hematopoietic stem cell transplant (HSCT). The goals of this study were identify patients with active infection caused by CMV in recipients of HSCT; determine the prevalence of CMV genotypes in the study group; correlate genotype with CMV disease, acute GVHD and overall survival.

Methods

The diagnosis of active CMV infection after allogeneic HSCT was detected by antigenemia (AGM) and/or nested-PCR (N-PCR). Positive samples from patients with active CMV infection were submitted to genotypi

SUBMITTER: Dieamant DC 

PROVIDER: S-EPMC3727998 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature