An IL6-correlated signature in serous epithelial ovarian cancer associates with growth factor response.

ABSTRACT:

Background

Epithelial ovarian cancer (EOC) is one of the most lethal gynecological cancers; the majority of EOC is the serous histotype and diagnosed at advanced stage. IL6 is the cytokine that has been found most frequently associated with carcinogenesis and progression of serous EOCs. IL6 is a growth-promoting and anti-apoptotic factor, and high plasma levels of IL6 in advanced stage EOCs correlate with poor prognosis. The objective of the present study was to identify IL6 co-regulated genes and gene network/s in EOCs.

Results

We applied bioinformatics tools on 7 publicly available data sets containing the gene expression profiles of 1262 EOC samples. By Pearson's correlation analysis we identified, in EOCs, an IL6-correlated gene signature containing 40 genes mainly assoc

SUBMITTER: Pinciroli P 

PROVIDER: S-EPMC3728068 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature