Osteopontin genetic variants are associated with overall survival in advanced non-small-cell lung cancer patients and bone metastasis.

ABSTRACT:

Purpose

Osteopontin (OPN) plays important roles in the modulation of apoptosis, angiogenesis, immune response, and tumor invasion. Elevated osteopontin expression has been reported in the lung cancer tissues compared to counterpart normal tissues. This study examined whether genetic variations in the osteopontin gene are associated with survival of lung cancer patients and occurrence rate of bone metastasis.

Experimental design

Three hundred and sixty patients with stages I to IV between 2003 and 2007 were recruited in this study and same number of healthy persons were used as control. Three promoter osteopontin polymorphisms, OPN-66 T/G, -156G/GG, and -443C/T variants were genotyped using DNA from blood lymphocytes. Chi-square test and a Fisher's exact test were used to ana

SUBMITTER: Chen Y 

PROVIDER: S-EPMC3728114 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature