Association of ADRB2 polymorphism with triglyceride levels in Tongans.

ABSTRACT:

Background

Our previous study demonstrated that the A-allele of the single nucleotide polymorphism (SNP) rs34623097 located in the upstream region of the β2 adrenergic receptor gene (ADRB2) is significantly associated with risk for obesity in Oceanic populations.

Methods

To investigate whether the ADRB2 polymorphisms explain part of the individual differences in lipid mobilization, energy expenditure and glycogen breakdown, the associations of 10 ADRB2 SNPs with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride levels were examined in 128 adults in Tonga.

Results

A multiple linear regression analysis adjusted for age, sex, and body mass index revealed that rs34623097 was significantly associated with triglyce

SUBMITTER: Naka I 

PROVIDER: S-EPMC3728115 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature