Frequency-risk and duration-risk relationships between aspirin use and gastric cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Although previous meta-analyses have suggested an association between aspirin use and risk of gastric cancer, current evidence is inconsistent. Additionally, it remains unclear whether there are frequency-risk and duration-risk relationships and if a threshold of effect exists.

Methods

We identified studies by searching MEDLINE and PUBMED databases and reviewing relevant articles. We derived the summary risk estimates using fixed-effects or random-effects model based on homogeneity analysis. The dose-response meta-analysis was performed by linear trend regression and restricted cubic spline regression. Potential heterogeneity was tested using the Q statistic and quantified with the I (2) statistic. Subgroup analyses and Galbraith plots were used to explore the pot

SUBMITTER: Ye X 

PROVIDER: S-EPMC3728206 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature