Quetiapine versus haloperidol in the treatment of delirium: a double-blind, randomized, controlled trial.

ABSTRACT:

Background

Atypical antipsychotic drugs may have low propensity to induce extrapyramidal side effects in delirious patients. This study aimed to compare the efficacy and tolerability between quetiapine and haloperidol in controlling delirious behavior.

Methods

A 7-day prospective, double-blind, randomized controlled trial was conducted from June 2009 to April 2011 in medically ill patients with delirium. Measures used for daily assessment included the Delirium Rating Scale-revised-98 (DRS-R-98) and total sleep time. The Clinical Global Impression, Improvement (CGI-I) and the Modified (nine-item) Simpson- Angus Scale were applied daily. The primary outcome was the DRS-R-98 severity scores. The data were analyzed on an intention-to-treat basis.

Results

Fifty-two subject

SUBMITTER: Maneeton B 

PROVIDER: S-EPMC3728270 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature